25 years later, Alejandro Ferrer is now the captain of the Federal Police and only seeks revenge against the narcos for destroying his family.

Roxana that after 25 years disappeared and ignoring that her brother is Alejandro enters a business of buying and selling diamonds.

After being detained and interrogated, Roxana enters the prison of Las Dunas, a boarding school with almost unique characteristics throughout Mexico, since it simultaneously houses, although in different pavilions, men and women deprived of liberty for being accused or condemned.

Roxana (Fernanda Castillo), who can no longer hide under the alias of "El Profesor", will fight to reestablish the Mil Cumbres cartel and grow her empire, but Alejandro (Raúl Méndez), commander of the Anti-Drug Unit, will not be willing to leave her now that he knows that "El Profesor" and her missing sister are the same person.

These conflicts between opposing sides unleashed a war of revenge between two blood brothers, now turned into worse enemies.