[12] For the One Day International series, Cricket South Africa appointed Quinton de Kock as the new captain of their ODI team, replacing Faf du Plessis.

[19] The day after the final T20I match, Faf du Plessis announced that he had stepped down as the captain of South Africa's Test and T20I sides.

[30] Prior to the second Test, Rory Burns suffered an ankle injury playing football and was ruled out of England's squad for the rest of the series.

[32] England's James Anderson suffered a rib injury on the final day of the second Test, and was ruled out of the rest of the series.

[36] England's Jofra Archer picked up an elbow injury during the Test series that eventually ruled him out of playing in the T20I matches.

[38] Ahead of the ODI series, Sisanda Magala was declared not to be fully fit, and was ruled out of South Africa's squad.