Born in Rome, Coltorti attended the Silvio D'Amico National Academy of Dramatic Arts and began acting and directing on stage in 1981, collaborating with Giorgio Albertazzi, Sergio Castellitto, Fiorenzo Fiorentini, Valeria Valeri, and Ennio Fantastichini, among others.

briganti!, also appearing in Ridley Scott's 2001 sequel to The Silence of the Lambs, Hannibal.

He is the primary Italian voice dubbing artist for Harvey Keitel and has also dubbed Willem Dafoe, J. K. Simmons, Billy Bob Thornton, Sam Shepard, Scott Glenn, Tom Waits and Martin Sheen in some of their films.

[5] Coltorti's popular character dubbing roles include Agent Smith (portrayed by Hugo Weaving) in The Matrix franchise and Professor X (portrayed by Patrick Stewart) in the X-Men film series.

In his animated roles, he dubbed Fillmore in the Cars franchise.