Enoch was born on March 10, 1767, or 1768 (his family records were destroyed by accident) in Lancaster County, Virginia.

However, his father moved his family to a place where there happened to be no evangelical clergy, such that Enoch became negligent of his religious duties, neglecting the Christian ordinances altogether.

George was sent by Bishop Francis Asbury to assist in forming a circuit on the headwaters of the Catawba and Broad rivers, in North Carolina.

The good bishop replied that "it was better for him to become inured to hardships while he was young, that when he was old and gray-headed his task would be easy."

But in 1800 he resumed his labors, and was appointed Presiding Elder of the Potomac District in the Baltimore Annual Conference.

Though many of these had little or no scholastic advantages, yet some became highly effective preachers of the Gospel, also attaining proficiency in Biblical and theological learning.

Bishop Matthew Simpson wrote of him: He was a man of deep piety, of great simplicity of manners, a pathetic, powerful and successful preacher, greatly beloved in life, and very extensively lamented in death.Bishop Enoch George died August 23, 1828, in Staunton, Virginia, and was buried in Mount Olivet Cemetery in Baltimore.