The program was the brainchild of Australian comedian, social critic, producer and media personality Andrew Denton, who hosted the show.
The show initially competed against the Nine Network's Micallef Tonight in the Monday 9:30 pm timeslot, and critics have claimed that Enough Rope's high ratings forced Nine to axe their program.
The show also included three 'On the Road' specials in which Denton travelled to a small country town and interviewed some of the local residents about their lives and experiences.
[5] Some of the high-profile international guests that appeared on the show include former U.S. President Bill Clinton, David Attenborough, Al Gore, Jerry Seinfeld, Jim Carrey, Bob Geldof, Antonio Banderas, Helen Mirren, Bono, Dave Grohl, Dr Jane Goodall, Elton John, Crown Princess Mary of Denmark, Angelina Jolie, Clint Eastwood, Mel Brooks, and Michael Parkinson.
A highly publicised interview with disgraced footballer Wayne Carey conducted in the weeks after a series of controversies drew in a television audience of 1.5 million viewers.