[1] Born and raised in Miami, Florida,[2][failed verification] Murciano attended Christopher Columbus High School[citation needed] and then Tulane University in New Orleans, Louisiana.

[3] He originally studied at New England School of Law in Boston for a time, but ultimately decided to pursue an acting career and left.

It was there that he met Jerry Bruckheimer, leading to him being offered a starring role as Danny Taylor in the CBS mystery drama Without a Trace.

In October 2009, Murciano appeared in the CBS police procedural drama CSI: Crime Scene Investigation in season 10: episode 4 titled "Coup de Gráce" (French for "stroke of mercy"), as Det.

In 2017, Murciano had a supporting role in the Netflix original film Bright as a gang leader named "Poison".