He was devoted to the arts from an early age and tried acting and theatre writing, with moderate success, before finally dedicating himself to tango.

Although his decision to write popular music was not unrelated from his previous exchanges with theatre and acting, his elder brother Armando resisted this move and therefore in the beginning things were not easy for Enrique.

Later that year, actress and singer Tita Merello rescued Que vachaché, and propelled it to the same popularity as Esta noche me emborracho.

He continued to gain fame the following years, and, in 1934, he wrote Cambalache, its lyrics not only describing the political climate of its era, but also nearly predicting its future.

Discépolo was versatile in his styling, having the ability to write songs that were ironic and moralistic, like Yira... yira..., Cambalache, romantic like Sueño de juventud, sarcastic (Justo el 31, Chorra), expressionist (Soy un arlequín, Quién más, quién menos), passionate (Confesión, Canción desesperada) and nostalgic (Uno, Cafetín de Buenos Aires).