The hospital is located in the central business district of the town of Entebbe, in Wakiso District, approximately 44 kilometres (27 mi), by road, southwest of Mulago National Referral Hospital, the largest hospital in the country, located in Kampala, Uganda's capital and largest city.

[3] Originally built by the British colonialists in the 20th century as Entebbe Grade B Hospital, the facility was closed temporarily in December 2013.

[4] Between December 2013 and May 2016, the hospital was rebuilt and expanded from 100 to 200 beds at a cost of US$7 million (about UGX:23.2 billion), donated by the World Bank.

Other services include pediatrics, radiology, laboratory, maternity, immunization, general surgery, internal medicine, orthopedics and operating rooms.

According to Dr Moses Muwanga, the medical director, at one time during the second wave, the 200-bed hospital had 160 Covid-19 inpatients.