Enterprise is an unincorporated community in Luce Township, Spencer County, in the U.S. state of Indiana.

[2] The first store opened in Enterprise in the 1830s, and the community was a landing stop for river boats in the mid-19th century.

[3] The town wasn't officially laid out until 1862.

[3] A post office was established at Enterprise in 1852, and remained in operation until it was discontinued in 1915.

This Spencer County, Indiana location article is a stub.