Enterprise City is one of three municipal school systems that take on-post Fort Novosel families at the secondary level.

The school was constructed with more than $45 million in disaster relief funding from FEMA, insurance settlements, and state approved grant money.

The twister collapsed parts of the building's science wing, third hallway and new gym, while causing severe damage in other areas of the school after impacting near Enterprise's municipal airport.

The final death toll was set at nine, including Ryan Mohler, Peter Dunn, AJ Jackson, Jamie Vidensek, Michael Bowen, Mikey Tompkins, Katie Strunk, Michelle Wilson, and an elderly woman named Edna Strickland.

The song "Held In His Love" by The Springs was written by Stewart Halcomb, a student inside Enterprise High School (Alabama) on March 1, 2007, and dedicated to the eight friends he lost that day.

In response to the tornado, Rachael Ray helped with the catering costs associated with the school's annual senior prom event (which was subsequently featured on the April 30, 2007, episode of her television show).

On May 3, 2007, The Red Jumpsuit Apparatus, The Skyline Drive, Course of Nature, May-Day, The Springs (band), and Brandon Kelly set up Band-Aid Benefit Concert sponsored by 106.7 WKMX in Fort Rucker, Alabama to help raise money for the high school.

Along with The Red Jumpsuit Apparatus and Course of Nature, Melissa Joan Hart supported husband, Mark Wilkerson of CON and the high school.