Entre-Deux is bordered by the communes of Cilaos, Saint-Benoît, Saint-Louis, Saint-Pierre and Le Tampon.

The village of Entre-Deux flourished thanks to the coffee trade introduced to the island in 1715, but the sugar cane has also had a significant success in the town.

After the 1950s, Entre-Deux underwent a series of changes to stop the economy from stagnating, with roads, buildings, reservoirs and electronic networks being set up in the town, as with much of the island, thanks in part to the French state.

Other trades, such as chicken farming, started up with moderate success, and now Entre-Deux is, along with Salazie, one of the main poultry centres of the island.

These days, only about 60% of the population is actively working, which is put down to the fact that businesses are reducing in number, seeing a recent rise in self-employment.