A station was opened at Whittlestone Head, north of Entwistle, on 12 June 1848 by the Bolton, Blackburn, Clitheroe and West Yorkshire Railway.

The 1871 Census of Population revealed that resident at Entwistle Station was SM William Davies, 24, his wife Ann, 23 and infant daughter Mary, 1, plus two family visitors, one being the railway telegraph clerk at Clitheroe.

The mills were demolished when the level of the Wayoh Reservoir was raised and the station was reduced in size following the Beeching report of 1963 and the singling of the Bromley Cross to Blackburn section of the line a decade later.

Typically for this branch line, a Yardley/Smith type 1 brick signal box opened here in 1876, situated on the Down side north of the station, containing an 18 lever Smith frame.

[8] Numerous highly detailed large scale original drawings survive for these track and related works from the early 1900s[9] Included with the plans is a letter sent by the railway company secretary to The Board of Trade in April 1904 which discloses that 'the old station has been reconstructed.

The signal box spanned the fast running lines and it is reported that it was a very draughty place of work, with its floorboards lifting like piano keys when a loco steaming hard passed underneath it.