Ephraim Leister Acker (January 11, 1827 – May 12, 1903) was an American newspaperman and educator who served one term as a Democratic member of the U.S. House of Representatives from Pennsylvania from 1871 to 1873.

He attended the common schools and the academy at Sumneytown, a village in Marlborough Township.

He was appointed postmaster of Norristown, Pennsylvania in March 1860 by President James Buchanan and after serving eleven months was removed by President Abraham Lincoln.

He was interred in Norris City Cemetery in East Norriton Township.

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