Ephraim Zalman Margulies (sometimes transcribed as Margolis) (19 December 1762 – 24 August 1828) (Hebrew: אפרים זלמן בן מנחם מאניש מרגליות) was a Galician rabbi born in Brody, brother of Chaim Mordechai Margulies.
He received his Talmudic education at different yeshivas, in which he distinguished himself for the acuteness of his intellect and for his astonishing memory.
In 1785 he published his responsa entitled Bet Hadash ha-Hadashot, and in the following year the rabbis of Brody elected him one of their number.
Being of independent means, he opened in his house a yeshivah of which he was the head; several of his pupils became eminent rabbis.
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