It has notable examples of the Queen Anne and Italianate architectural styles and buildings designed by noted Lancaster architect C. Emlen Urban.

Sprecher & Sons Hardware (1911), Richard Heitler House (1820), J.W.

Yost Liquor Store (c. 1880), Ephrata Railroad Station (1887–1889), U.S. Post Office (1937), Ephrata National Bank (1925), and Grant and Wenger Feed Mill (1924).

Located in the district is the separately listed Mentzer Building.

This article about a property in Lancaster County, Pennsylvania on the National Register of Historic Places is a stub.