[3] Many blister beetles have a complex developmental cycle in which the larva and pupa experience drastic changes in morphology between growth phases.

[1] There are one or two generations per year, with peak abundance of adults in the summer, or slightly earlier in more hospitable climate types.

It also feeds on a variety of crop plants, including beans, beet, carrot, cabbages, corn, eggplant, pea, potato, radish, spinach, squash, sweet potato, tomato, turnip, clovers, soybean, and alfalfa.

It feeds voraciously, prefers crop plants, damages fruits, and forms swarms that travel en masse.

[4] The toxic dose of cantharidin in horses is about one milligram per kilogram body weight, and the ingestion of 30 to 50 beetles can be fatal.

[4] Signs of toxicity include blisters and ulcers of the mouth, pawing, stretching, diarrhea containing bits of intestinal mucosa, hypocalcaemia, and hypomagnesemia.

[4] Predators of the striped blister beetle include robber flies and several birds, such as the western meadowlark, eastern bluebird, and scissor-tailed flycatcher.

[3] Frogs are apparently not affected by Meloidae beetle toxin, and "consume meloids with impunity".

Northern leopard frogs fed striped blister beetles in studies accumulated cantharidin in their thigh muscles, among other tissues.