[4] Like its predecessor, the gameplay in Epidemic focuses on traversing corridor-like environments, destroying enemy robots and finding key cards to reach inaccessible areas.

In order to save Layla, her doctor tells Masao that the only way to cure her Gigari is through the Lafres Flower, only grown on the surface.

Upon getting the info he needed and heading to the Satavisa ruins, Masao comes across another of his allies from his days in Del Sol; Jeff Sanders.

After gathering the Lafres flower on the surface and curing Layla's condition, Masao tells Jim about his encounter with Sanders and plans to help him with the situation with Carlos.

Despite reaching the new Power Armor, Masao informs Jim about Sanders' passing, and wants his revenge by going to the tower and saving Carlos.

After following Layla to the headquarters, Masao falls victim to the Gigari virus due to his earlier exposure on the surface, and must find an antidote in the building.

Byflos dies, Masao ponders the attack, and upon returning to Jim, he realizes that Sirus has turned against him and is now coded to believe that it must continue Kileak's ideology by 'protecting the human race' by protecting itself.

[10] Next Generation reviewed the PlayStation version of the game, rating it two stars out of five, and stated that "Even after all the improvements, however, Kileak 2 is still an average Doom-clone that offers nothing new to the genre.