Epidendrum blepharistes is a species of orchid in the genus Epidendrum native to Bolivia, Colombia, Costa Rica, Ecuador, Peru, and Venezuela.

Amphiglottium, E. blepharistes exhibits a sympodial growth habit, with individual stems covered from the base with close, tubular sheaths; on the upper part of the stem, these sheaths are the bases of the distichous leaves.

Amphiglottium by frequently having a fusiform swelling, up to 1.5 dm long, at the base of each stem.

The terminal peduncle is covered from its base in close tubular sheaths, and carries either a loose panicle (typical of the section E. sect.

The small flowers are a rich rose color with oval sepals up to 10 mm long by 4 mm wide, acuminate petals nearly the same length as the sepals but with a denticulate margin, and a quadrilobate lip which is adnate to the column to its apex.