E. flexuosum bears non-resupinate lavender flowers on a congested raceme at the end of a long peduncle.

In the wild, Epidendrum flexuosum grows naturally together with a nest of ants,[2] and sometimes bees, wasps, or hornets,[3] which protect it from predators.

This species is very difficult to grow without the ants, a phenomenon found in other genera such as Caularthron, Coryanthes, and Sievekingia.

Amphiglottium[4] and shares the characteristics of that subgenus: it exhibits a sympodial growth habit with slender, unswollen stems covered by close distichous sheathes which are foliaceous on the upper sections of the stem; the inflorescence is terminal and covered from its base by distichous sheathes; and the lip is adnate to the column to its apex.

The chromosome number of an individual collected in Mamirauá, Brazil has been determined as 2n = 28[8] List of synonyms:[9] Images in the wild (as E. imatophyllum): https://web.archive.org/web/20080308035848/http://www.abundaflora.com/epi_imat.htm