Epigenes is a lunar impact crater that is located in the north part of the Moon, and is sufficiently close to the northern limb to appear significantly foreshortened from the Earth.

Due north of Epigenes is Goldschmidt, and the ruined crater Birmingham lies just to the southwest.

The western half of the interior floor is smooth and nearly featureless, while the remainder is somewhat hummocky and appears covered in ejecta from the east.

The small crater Epigenes B intrudes into the northeastern rim.

[1] By convention these features are identified on lunar maps by placing the letter on the side of the crater midpoint that is closest to Epigenes.