It publishes commentary articles, written by a board of contributing editors, and brief topical reviews.

Content is available on the society's web site and on PubMed Central.

The journal began to be self-published by the society in collaboration with Allen Press in 2011; prior to that time the journal was published on behalf of the society by Wiley-Blackwell.

The journal is abstracted and indexed in Academic Search, CSA Biological Sciences Database, Neurosciences Abstracts, PubMed Central, Science Citation Index Expanded, and Current Contents/Clinical Medicine.

In December 2008, Gregory K. Bergey and Michael A. Rogawski (then at UC Davis School of Medicine) were appointed editors-in-chief.