The 48.6 acres (19.7 ha) site rests on a plateau 100 feet (30 m) above the Moselle River in the foothills of the Vosges Mountains.

It contains the graves of 5,255 of the United States' military dead, most of whom lost their lives in the campaigns across northeastern France to the Rhine and beyond into Germany during World War II.

At the northern end of the mall, the circular flagpole plaza forms an overlook affording a view of a wide sweep of the Moselle Valley.

Epinal American Cemetery is located approximately 4 miles (7 km) southeast of Épinal (Vosges), France, on road D-157, in the village of Dinozé-Le Quéquement.

When the cemetery is open to the public, a staff member is on duty in the Visitor Building to answer questions and escort relatives to grave and memorial sites.