Epinephelus flavocaeruleus, commonly called blue-and-yellow grouper, is a species of marine ray-finned fish, a grouper from the subfamily Epinephelinae which is part of the family Serranidae, which also includes the anthias and sea basses.

Along the eastern coast of Africa from Djibouti to Port Alfred east to Sumatra.

It has been recorded around St Brandon and Rodrigues in the Mascarenes and as far north as the Gulf of Mannar in India.

The juveniles are found in shallow reefs whereas the adults occur on deeper reefs to 150 metres (490 ft)[6] This predatory species feeds on fishes, crabs, shrimps, spiny lobsters, squids, and small octopuses.

In the Maldives, it is captured for export to the Hong Kong live reef fish market.