The guitar debuted in 1961 and has been associated with such guitarists as Howlin' Wolf, Phil Upchurch, George Harrison, John Lennon, Paul McCartney, Noel Gallagher, Keith Richards, Dave Davies, Brad Whitford, Shirley Manson, Paul Weller, The Edge, Josh Homme, Daniel Kessler, Brendon Urie, Gary Clark, Jr., Glenn Frey, John Illsley, and Peter Green.

[1][3] With the exception of the John Lennon models, subsequent Casinos have been made with 14-degree headstock angle with five layer all maple laminated tops.

[5] Lennon used the Epiphone Casino as his main electric instrument during the remainder of his time with the Beatles, replacing the Rickenbacker 325.

In 1968 when the band were traveling in India, Donovan told Lennon and Harrison that sanding the finish off their Casinos would improve the tone.

[6][7][8][9] In the early seventies, Lennon replaced the original nickel Kluson tuners on his Casino with a set of gold Grover machine heads.