Eppler started his academic career as lecturer and project manager at the University of Geneva, while also working as consultant for the Geneva Knowledge Group.
He then moved back to the University of St. Gallen, where he was appointed Senior Lecturer and Vice Director of the Institute for Media and Communication Management.
In 2003 he was appointed Professor of Information and Communication Management at the University of Lugano, and since 2009 he is Professor of Media and Communication management at the University of St. Gallen, head of the ISP MBA program, and director of its Institute for Media and Communication Management.
He was a member of the editorial board of the reviews "OrganisationsEntwicklung," and formerly the "Journal of Universal Knowledge Management, and of "Studies in Communication Sciences," and "Information & Management.
"[2] Eppler published 24 books and more than 300 articles in the fields of management, organization studies, communication, and visualization.