Eraño completed his elementary education at St. John's Academy in San Juan, Metro Manila, starting at the age of six.

[5] With the death of Felix Y. Manalo on April 12, 1963, Iglesia's critics predicted the church's decline and eventual fall.

Barely a month after assuming his role as spiritual leader of the church, the young Manalo began visiting congregations nationwide.

At every location he visited, he officiated worship services and staged massive religious rallies in public plazas.

As early as 1967, four years after assuming leadership role, Manalo set his vision to overseas mission and global expansion.

The following month, the Executive Minister was in California to establish the San Francisco congregation and lead its inaugural worship service.

In June 1987, the US Main Office (USMO) was set up in Daly City, California to assist the INC central administration in supervising the then 11 districts of the church in the West.

Missions have also opened in Kazakh SSR (now Kazakhstan) and Sakhalin Island in Russian SFSR (now Russia).

The Ministerial Institute of Development, currently the New Era University College of Evangelical Ministry (later called as Iglesia ni Cristo School for Ministers), was founded in 1974 in Quiapo, Manila.

In 1965, INC launched its first resettlement and land reform program in Barrio Maligaya, Laur, Nueva Ecija.

The complex also includes the New Era University, a higher-education institution run by the INC. INC Spokesperson and General Evangelist, Bienvenido C. Santiago Sr, confirmed Manalo's death in an announcement delivered in Filipino/Tagalog over various radio and television stations including Net 25 (along with sister station DZEC-AM),[8] translated below: We are sad to inform the whole Church and the entire community that the executive minister of the Iglesia ni Cristo that brother Eraño G. Manalo has passed away, died at his home at about 3:53 PM , yesterday, August 31, 2009, at age 84, according to his physician Dr. Ray Melchor Santos, the cause of his death, was cardiopulmonary arrest, his body lay in the Central Temple of the Iglesia ni Cristo in Quezon City.

We ask the ministers and workers with duties and affiliations that we pray to God that He will continue to guide the whole Iglesia ni Cristo and grant us strength during this time of great distress.

[9]Santiago also stated that according to Dr. Ray Melchor Santos, Manalo died due to cardiopulmonary arrest.

Ordinance number SP-1961 S-2009 the Quezon City Council stated the renaming was to is recognition of "“his greatness and nobility” in leading the powerful religious group.

"[11] On April 13, 2010, The Philippine Postal Corporation announced that it will issue a limited edition postage stamp in his honour.