[1] In Search of the Antidote explores themes of "identity, insecurity, ego, and self-fulfillment", containing "distinct production" as well as "powerful vocal delivery".

Talking about the topic, Fletcher revealed that she had been looking for "the antidote in so many things" over the years, such as "women, the road, the stage, fans, spirituality and self-reflection".

[10] In the weeks leading up to the release of In Search of the Antidote, Fletcher took part in interviews on the Zach Sang Show and with Zane Lowe for Apple Music.

[20] Eryn Murphy with Euphoria Magazine gave In Search of the Antidote four out of five stars and called the album a "transparent pop journey".

[21] In a five-star review, Neive McCarthy with Dork wrote that "Fletcher delivers her truths and lessons with some of her most electric tracks yet" on In Search of the Antidote.