He has written three biographies, Amazing Grace: William Wilberforce and the Heroic Campaign to End Slavery about William Wilberforce (2007), Bonhoeffer: Pastor, Martyr, Prophet, Spy about Dietrich Bonhoeffer (2011), and Martin Luther: The Man Who Rediscovered God and Changed the World (2017).

He also published a memoir, Fish Out of Water: A Search for the Meaning of Life (2021) as well as several books, including If You Can Keep it (2017) and Letter to the American Church (2022).

"[8] Metaxas is the author of more than thirty children's books, including the bestsellers Squanto and the Miracle of Thanksgiving[9] and It's Time to Sleep, My Love, illustrated by Nancy Tillman.

Metaxas's works If You Can Keep It: The Forgotten Promise of American Liberty and Miracles: What They Are, Why They Happen, and How They Can Change Your Life are both New York Times bestselling books.

[25] Carlos Eire gave the book a full page review in the New York Times, stating, "Metaxas knows how to tell a story and how to develop characters, and this talent makes his narrative at once gripping and accessible."

But he also accused Metaxas of doing naive Whig history, portraying Luther as "a titanic figure who single-handedly slays the dragon of the Dark Ages, rescues God from an interpretive dungeon, invents individual freedom and ushers in modernity.

In order to reach his conclusions, Vidmar writes, "Metaxas needs to misunderstand, denigrate, and then caricature centuries of human effort and achievement in language that is colloquial, casual, and often flippant.

[39][40] In an appearance on Charlie Kirk's show, he repeated the claim saying, “We need to fight to the death, to the last drop of blood.”[41] Amid the COVID-19 pandemic, Metaxas told his followers not to get the vaccine.

[43] Notable guests have included Dick Cavett, David Brooks, Kirsten Powers, Kathie Lee Gifford, N. T. Wright, Peter Hitchens (brother of Christopher Hitchens), Jimmie "J.J." Walker, Andrew Garfield,[44] Maria Butina,[45] Milo Yiannopoulos,[46] Ross Douthat, Tony Shalhoub, Morgan Freeman, Jeff Allen, Senator Rand Paul, Joseph Fiennes, Darryl Strawberry, and Suzy Welch.

[49][50] In the late 1990s Metaxas wrote BreakPoint radio commentaries for former Richard Nixon aide and Prison Fellowship founder Charles "Chuck" Colson.

Upon Colson's death in 2012, Metaxas, along with John Stonestreet, became the voice of BreakPoint, which now airs weekdays on 1350 outlets across the country.

[52] Metaxas has testified before Congress about the rise of anti-Semitism in the U.S. and abroad, and he spoke at the Conservative Political Action Conference in 2013 and 2014 on the issue of Religious Freedom.

[58][59][60][61] On August 27, 2020, Eric Metaxas was at Trump's Republican National Convention acceptance speech on the White House lawn.

Afterwards, Metaxas left the White House with a crowd of people, entering streets where protesters had been staging demonstrations.