He is known for his books Fast Food Nation (2001), Reefer Madness (2003), and Command and Control: Nuclear Weapons, the Damascus Accident, and the Illusion of Safety (2013).

[9] Schlosser's book Command and Control: Nuclear Weapons, the Damascus Accident, and the Illusion of Safety was published in September 2013.

[11][12] The New Yorker's Louis Menand called it "excellent" and "hair-raising" and said that "Command and Control is how nonfiction should be written.

[15] Schlosser appeared in an interview for the DVD of Morgan Spurlock's Super Size Me, having a one-on-one discussion with the filmmaker about the fast-food industry.

In 2014, he was an executive producer of the farmworker documentary Food Chains,[16] a credit he shared with Eva Longoria.

[17] Schlosser also shared a director credit for the multimedia installation entitled "the bomb", an experimental film about nuclear weaponry coupled with a live score by The Acid.