He played for the Pittsburgh Penguins, Winnipeg Jets, Montreal Canadiens, Detroit Red Wings, New Jersey Devils, and Barys Nur-Sultan in the Kontinental Hockey League (KHL).

On February 26, 2009, Tangradi was traded along with Anaheim Ducks forward Chris Kunitz to the Pittsburgh Penguins in exchange for defenseman Ryan Whitney.

Tangradi at seasons end was named the Belleville Bulls Humanitarian of the Year, Most Outstanding Forward, and Top Scorer.

After being reassigned to Wilkes-Barre/Scranton on December 8, 2010, Tangradi scored his first professional hat trick against goalies Jussi Rynnas and Ben Scrivens of the Toronto Marlies.

On April 18, 2012, Tangradi tallied his first NHL playoff point against his hometown Philadelphia Flyers, assisting on a Jordan Staal goal.

[18] As a free agent from the Devils, Tangradi opted to sign his first contract overseas, agreeing to terms with Barys Nur-Sultan on August 19, 2019.

[19] After scoring nine points (five goals, four assists) in 22 games with Barys, Tangradi returned to North America by signing a one-year AHL contract with his old team, the Grand Rapids Griffins, on December 6, 2019.

[22] Tangradi is a dog lover, and owns a Boxer named Carson in honor of the street in Pittsburgh where he met his wife, Caitlyn Hess.

[23] A Penn State graduate with an interest for fashion, Hess started SCHEÉ (pronounced SHE-ay), a shoe company with a philanthropic twist where a percentage of each sale goes to a charity.

[24] In June, 2022 Tangradi announced that he would become head coach of Shady Side Academy's boy's prep hockey team.