He served congregations in Lynbrook, New York and Durham, North Carolina, before joining the URJ as director of the Midwest Council in 1980.
Jonathan Sarna observed that Yoffie, during his presidency of the URJ, urged Reform Jews to enrich their spiritual lives and expand their knowledge of Judaism.
[9] In 2005, he introduced the Sacred Choices curriculum, which focused on teaching sexual ethics to teenagers in Reform camps and congregations.
[13] In his remarks, he discussed shared values of family and morality, as well as differences, including church-state separation and gay marriage, which drew boos from some students.
[1] On August 21, 2007, Rabbi Yoffie became the first leader of a major Jewish organization to address the convention of the Islamic Society of North America.
"[16] As President of the Union for Reform Judaism (URJ), Rabbi Yoffie addressed a range of social justice issues.
He was the only religious leader to speak at the Million Mom March, where he stated that "the indiscriminate distribution of guns is an offense against God and humanity."
As President of the URJ, he met frequently with Israeli officials to convey the concerns of the Reform movement and North American Jewry.
[21][22] Rabbi Yoffie has written on belief and spirituality in American life, addressing topics such as sin, atheism, community, immigration, health care, and economic justice from a progressive religious perspective.
In What it Means to be a Liberal Person of Faith[23] and other writings, he stated that progressive religion has a role in the modern era.