The swelling of the stems was assumed to have been influenced by the presence of gall insects, most notably of the genus Odynerus.

The female wasp produces a small hole on the inflated portion of the desert trumpet, packs the cavity with larvae and lays her eggs upon them, providing a food source, and a protected environment for the offspring.

Recently, research performed by a world authority on the genus Eriogonum, Dr. J. L. Reveal of the University of Maryland, College Park, revealed the swollen stem of Eriogonum inflatum is due to high concentrations of carbon dioxide in the solid stem and seems to be related to gas regulation.

It is known that some Native American tribes that once inhabited the surrounding areas of the Las Vegas Valley (most commonly Paiute) would remove the stalk of E. inflatum at the base, and then cut the inflated bulb in half, producing a makeshift pipe.

This plant makes a brief appearance in Star Trek: Voyager, in Season 3, episode 1, at around the 3 minute 47 second mark, when the character "Neelix" is shown to be looking at a picked specimen.