Born in Turin, Macario made his debut at a young age in the amateur dramatics company Don Bosco Oratory in Valdocco,[1] then he was part of some small amateur companies in his hometown until 1924.

[2] Soon after, he entered the company of Wanda Osiris, the undisputed queen of the revue of that time in Italy.

[3] Macario made his film debut in 1933 with Aria di paese, but the success came just six years later with two comedy films directed by Mario Mattoli and co-written by a young Federico Fellini, Imputato alzatevi!

[2] After a series of successful comedies directed by Carlo Borghesio since the early fifties, Macario appeared in short characterizations in anthology films and was sidekick of Totò in a number of films.

[2] His comical style was referred to as a mixture between Chaplin's Charlot and Marx Brothers.