The club's full original name was Gymnastikos Syllogos Agias Ermis Larisa (Γυμναστικός Σύλλογος Επαρχίας Αγιάς Ερμής Λάρισα).

Their highest position in the league's final standings has been the 4th, achieved during the 2021-2022 campaign, under coach Fotis Takianos.

The club's professional future has been in disarray since the departure of owner and president Theodoros Rizoulis in the summer of 2022.

With the club originally being located in Agia, Larissa (regional unit), Greece.

Ermis Agias Larisa was given a wild card place in the top-tier level Greek Basket League's 2019–20 season.