In 1972, he joined River Plate but he never won any titles during his time with the club.

He joined Unión de Santa Fe in 1975, but in early 1976 he was signed by River Plate's eternal rivals Boca Juniors.

Mastrángelo was twice Boca's top scoring player, in 1977 and 1979, he retired in 1981 after the team won the Metropolitano championship.

Ernesto Mastrángelo died from idiopathic pulmonary fibrosis in Buenos Aires, on 22 July 2023, at the age of 75.

[3] Boca Juniors This biographical article related to an Argentine association football forward born in the 1940s is a stub.