In 1998 Scorsone was the Democratic nominee for the open 6th district seat in the United States House of Representatives, but he lost the general election to Republican Ernie Fletcher by seven points (53%–46%).

[citation needed] He led the legal battle to overturn Kentucky's sodomy statute and a successful legislative fight against a constitutional amendment to reinstate the law.

[citation needed] Scorsone successfully worked to amend the state's penal code to include, the first time, a hate crime provision based on sexual orientation and helped organize the campaign for a fairness ordinance in Lexington to protect employment, housing and accommodation.

{citation needed} He successfully petitioned and helped draft a gubernatorial executive order in 2003 protecting LGBT state employees from job discrimination.

"[4] In May 2017, Judge Scorsone held a hearing upon a defendant's pre-trial motion asserting an applied challenge to the death penalty brought forth within Commonwealth of Kentucky v. Travis Bredhold, who was 18 years and 5 months old when he was charged in 2013 with murder and robbery in the fatal shooting of a Marathon gas station attendant.

Therefore, in light of the scientific evidence, the evolving standards of decency would preclude the death penalty within the Commonwealth's case since the defendant was under the age of twenty-one (21) years old at the time of the crime.

[5] "Contrary to the commonwealth’s assertion, it appears there is a very clear national consensus trending toward restricting the death penalty, especially in cases where defendants are 18 to 21 years of age," Scorsone wrote in his opinion.

The age group lacks maturity to control their impulses and fully consider risks, making them unlikely to be deterred by knowledge of likelihood and severity of punishment, the judge wrote.

[7] Scorsone's civic activities include service with numerous organizations that support the Lexington/Fayette County community and its citizens as well as Kentuckians' interests statewide.