He fought in the First World War in the infantry and left the German Army with the rank of first lieutenant (Oberleutnant) in 1919.

Boepple became a co-worker of the publisher Julius Friedrich Lehmann and was one of the founders of the German Workers' Party (DAP).

[3] The Deutsche Volksverlag published a large section of the early formative Nazi literature including:[4] In November 1923 Ernst Boepple took part in the Beer Hall Putsch.

When Hans Schemm died after an aircraft crash, Boepple became the Bavarian Minister for Culture until the invasion of Poland in 1939.

Boepple was deeply implicated in the Final Solution as the deputy to Bühler and also held rank in the SS, being an SS-Oberführer (senior colonel).