He earned cups of coffee in the majors with the Cards in 1941 and 1942, and missed the 1943 to 1945 seasons while serving in the United States Army in the Pacific Theater of World War II.

On July 7, 1946, he hit a game-winning, three-run home run to beat the Brooklyn Dodgers and to move his club within a half game of the National League lead.

Dusak played a key role in the clinching second game of the series, hitting a triple and an RBI single to help propel the Redbirds to the 8–4 triumph.

When his batting average dropped, he turned to pitching, appearing in 23 games, all in relief, but ended his career primarily as a position player with the Pittsburgh Pirates.

In 413 MLB games played over all or part of nine major-league seasons, Dusak batted .243; his 251 hits included 32 doubles, six triples and 24 homers, with 106 RBI.