[3][5][10] Erysimum collinum is native to southeastern Russia, Armenia, Turkey, Georgia, Azerbaijan, Iraq, and Iran, where it grows at altitudes from 700 to 1390 m.[5] Habitats where E. collinum is found include cultivated fields, river banks, and rocky areas.

In a 2014 taxonomic revision, E. aucherianum, E. gayanum, E. gracile, and E. passgalense are considered to be the same species as E.

[5] Based on sequence comparisons of expressed genes in 48 Erysimum species, E. collinum is most closely related to E. crassipes and E.

[12] However, unlike other analyzed members of the genus Erysimum, E. collinum contains only trace amounts of cardiac glycosides (cardenolides).

[11] Nevertheless, extracts of E. collinum showed some inhibitory activity of the mammalian sodium-potassium ATPase pump (Na+/K+-ATPase), the main molecular target of cardenolides.