Rund um den Henninger Turm received a status upgrade in 1967 when Paris–Brussels, organised in late April, was removed from the calendar due to traffic problems and the event became the pre-eminent one-day cycling race in West Germany.

Barry Hoban became the first British winner in 1966 after a 50 km solo ride to the finish, holding the chasing pack at one minute.

In 1995, Rund um den Henninger Turm was part of the UCI Road World Cup, cycling's season-long competition of the most important one-day races in the 1990s.

The fixed date of the event however, every 1 May, was considered unfavourable as it was often midweek, and it was replaced with the newly created HEW Cyclassics in Hamburg as the German leg of the series.

Since the event's restyling in 2009, the race starts in Eschborn, 13 kilometres (8.1 mi) west of Frankfurt – the finish was at the housing development Riedberg.