Although it was held a few years before 1924 already, it gained official status in 1924 as the national football association was founded in 1923 and began organising the regional leagues.
In the period from 1924 to 1935, the winners of the Eskişehir League qualified for the former Turkish Football Championship.
In 1940 Eskişehir Demirspor won the Turkish championship against Fenerbahçe, marking a turning point in Turkish football as clubs from Istanbul, Ankara, and İzmir were the dominating sides in those decades.
Eskişehir Demirspor hold the record with 22 championship titles won.
The following teams participated in the league regularly for at least a few years: