She took the lead in the last 200 metres but was caught in the final strides and beaten a neck by the Breeders' Cup Juvenile Fillies Turf winner Flotilla.
Esoterique tracked the leaders before accelerating into the lead a furlong out and got the better of a sustained "duel" with Integral to win by a head, with the pair finishing more than three lengths clear of the other five runners.
[6] She returned to England in June for the Duke of Cambridge Stakes at Royal Ascot, but tired badly in the closing stages and finished unplaced behind Integral.
On her return to France, Esoterique started the 12/1 outsider in a four-runner field in the Group One Prix Rothschild over 1600 metres at Deauville Racecourse on 3 August.
[7] In September she was matched against colts in the Prix du Moulin at Longchamp and finished fourth behind Charm Spirit, Toronado and Night of Thunder, beaten less than one and a half lengths by the winner.
On her final appearance of the season met Integral again when the pair started co-favourites alongside Miss France and the Prix de Sandringham winner Fintry in the Sun Chariot Stkes at Newmarket on 4 October.
In June she was sent for the second time to Royal Ascot and started a 16/1 outsider in a much-anticipated race for the Queen Anne Stakes which attracted eight runners including Solow, Able Friend, Night of Thunder and Toormore.
The other seven runners, in a race run on very soft ground included the Breeders' Cup Mile winner Karakontie and Belardo, the top-rated European two-year-old of 2014.
Despite Boudot dropping his whip in the closing stages, Esoterique prevailed to win by half a length with Irish Rookie taking third ahead of Fadhayyil.
She was restrained in the early stages in a slowly-run race and although she made some late progress she never looked likely to win and finished seventh of the twelve runners behind Tepin.
Esoterique began hew 2016 in the Pris du Palais Royal at Deauville on 4 June: she started odds-on favourite but was beaten two lengths into second place by the three-year-old colt Attendu.