The most titled club in the country, Espérance Sportive de Tunis joined the national division at the end of the 1958–1959 season with a squad led by Moncef Hajjar, Lamine Kallel, Chedly Ben Slimane, and Mongi Haddad.

Subsequently, the team won its first title in 1963 by defeating Al Mansoura Chaabia of Hammam Lif in the cup final.

Among its key players were Moncef Hajjar, Mounir Jelili, Moncef Besbes, Fawzi Sbabti, Faouzi Ksouri, Khaled Achour, Zouheir Khenissi, Habib Yagouta, Sami Agrebi, Mohamed Madi, Karim Zaghouani, Issam Tej, Wissem Hmam, Jaleleddine Touati, Mahmoud Gharbi, and Heykel Megannem.

Espérance's dominance extended to the Arab Club Championship, where they won the first four editions before boycotting the competition for non-sporting reasons.

The team participated in the IHF Men's Super Globe in 2014, 2016, 2017, and 2022.