Esperanza Martínez Lleida de Portillo (born 26 April 1959) is a Paraguayan medical doctor and politician, currently serving as senator since 2013.

She previously served as Minister of Public Health and Social Welfare from 2008 to 2012, under President Fernando Lugo.

[1] In May 2012 she was elected vice-president for the 65th World Health Assembly of the World Health Organization.

[2] She is an advocate of liberalizing implementation of laws regarding abortion in Paraguay to help a pregnant 10-year-old who was raped by her stepfather, complaining that to those who opposed the treatment, the unnamed girl "became a uterus.

"[3] This article about a Paraguayan politician is a stub.