Founded by Brazilian cartoonist Mauricio de Sousa, it was originally dedicated to the production of comic strips published in the newspapers in the late 1960s and early 1970s, Mauricio started a partnership for the publication of magazines with Editora Abril, which lasted until the mid-1980s when, to increase circulation, changed to Editora Globo.

During this same period he produced some animated feature films, an initiative that did not provide the desired return, as Mauricio himself assured.

On January 1, 2007, Mauricio de Sousa Produções (a name that encompasses all of the author's editorial initiatives) left Globo, signing an "exclusive and long-lasting" agreement with Panini Comics.

Currently, Mauricio de Sousa Studio works with Mauricio's newest release: the manga Monica Teen – which, however, was expected to sell a maximum of 60,000 copies in its first edition but due to its great success sold more than 230,000 copies.

Mauricio de Sousa Produções changed its address on January 25, 2017.