[1] The station, inaugurated on 20 December 1882, is located in the barrio of Balvanera, immediately north of Plaza Miserere, a large public square.

As a consequence, that first Once de Septiembre station was a modest building made of wood and placed on Bartolomé Mitre street.

In April 1878, the Municipality of Buenos Aires thus promulgated by decree the closing of the Once–Del Parque section of the railway line, as well as the moving of the terminal station to Once, though it did not take effect until 1883.

On 22 February 2012, a commuter train entered Once station traveling at an excessive speed, about 26 km/h, and crashed into the buffers at the end of the line, killing 51 people and injuring at least 703.

The publicly owned provincial railway company Ferrobaires operates trains over four principal rail lines which fan out west over the surrounding Buenos Aires Province.

operates a regular train service to the suburbs of Buenos Aires along the branches of its Sarmiento Line to destinations including Moreno, Luján, Lobos, and Mercedes.