Built in 1962, under the mayoral administration of Felisa Rincón de Gautier as a replacement for Estadio Sixto Escobar, it was added to the National Register of Historic Places in 2014.

When the Expos played home games at Hiram Bithorn, the field dimensions were set to match Olympic Stadium in Montreal.

The first outdoor National Basketball Association game was played between the Phoenix Suns and the Milwaukee Bucks on September 24, 1972, during that year's preseason.

In 2010, Major League Baseball returned to the stadium, as the Florida Marlins faced the New York Mets in a three-game series during the regular season.

However, on May 6, 2016, it was announced that the Puerto Rico games would be postponed due to the Zika virus outbreak, and moved to Marlins Park.

[6] The Cleveland Indians and Minnesota Twins played a two-game series at Hiram Bithorn Stadium on April 17 and 18, 2018.

On March 10, 11, and 12 of 2023, the Colombian singer Karol G performed three special shows at the stadium, in support of her 2023 album Mañana Será Bonito.