Ηer first works were Romeo and Juliet and a small role in La Patria en Armas by Juan León Bengoa.

Among her most remembered works are: With the one-person show Retablo de Vida y Muerte, she toured internationally, performing in Spain, France, Portugal, the Netherlands, Italy, England, the United States, Honduras, Guatemala, Venezuela, and Colombia in 1977–1978.

She premiered the 2010 production, The Rules of Urbanity in the Modern Society by Jean-Luc Lagarce, under the direction of Rubén Szuchmacher, a show that later took her to Buenos Aires.

[10] Medina starred in the 2016 play En La Laguna Dorada, by Ernest Thompson, again directed by Gerardo Begérez at the Teatro Circular in Montevideo, in a season that lasted through the year.

On August 25, 2018, the play La golondrina premiered at the Teatro del Notariado, directed by Gerardo Begérez, which deals with the terrorist attack on the Pulse bar in Florida.

And she also won four times for Supporting Actress: in 1970 for Mercy Croft from The Murder of Nurse George; in 1981 as Leonor from Los Cuentos del Final; in 1985 for Ariane Mnouchkine's Myriam de Mefisto; and in 2001 for Lady A from Three Tall Women.

[13] In 2004, she was declared an Illustrious Citizen of Montevideo, receiving the Keys to the city from Mariano Arana, during the Reopening Ceremony of the Solís Theater.

[14] On November 22, 2005, the Government of France named her Chevalier de l'Ordre des Arts et des Lettres, in a ceremony held by the French Ambassador Rapin in Uruguay; a distinction that is granted to those who, in addition to having a noteworthy career in their trade, have promoted cultural exhanges between Uruguay and France with their work.

[14] On April 30, 2010, she received the appointment of Dame of the Order of Isabel la Católica, which was granted to her by King Juan Carlos I of Spain for her dissemination of the Spanish classics.

[19] On August 18, 2015, she was named Honorary Academician of the National Academy of Letters of Uruguay, a distinction that she thanked with a lyrical-dramatic recital in lieu of a speech.