Born in Milan, Mendicino began his career in Rome with the successful Lazio youth system.
Playing as a centre-forward and earmarked as a potential future-Luca Toni, Mendicino was touted as a key member of Lazio's future.
[1] At the beginning of the 2008–09 season, Mendicino played for the first team in pre-season friendlies, having a goal wrongfully disallowed against Liverpool at Anfield.
[2] On 8 February 2009, Mendicino made his Serie A debut, coming on as an injury time substitute for Cristian Ledesma in Lazio's 1–0 loss to Fiorentina.
[6] On 27 September 2021 he moved to Sambenedettese in Serie D.[7] On 25 March 2009 Mendicino made his debut with the Italy U-21 squad in a friendly match against Austria.