It has rough bark on the base of the stems, smooth grey to brown bark above, heart-shaped to egg-shaped adult leaves arranged in opposite pairs, flower buds in groups of seven to eleven, pale yellow flowers and cup-shaped to barrel-shaped fruit.

The bark is rough and fibrous on the base of the trunk, sometimes to the larger branches, and smooth grey to brown or cream-coloured above.

[4][5][6] Eucalyptus wyolensis was first formally described in 1988 by Clifford David Boomsma in the Journal of the Adelaide Botanic Garden from specimens collected west of Carle Thulka and south of Lake Wyola in 1987.

[7][8] The specific epithet and the common name is a reference to its occurrence near Lake Wyola in the Great Victoria Desert.

[4] This mallee is only known from two populations between Lake Maurice and the border with Western Australia where it grows on red sandplain[4] in the southern part of the Great Victoria Desert.